Tesserie

Works.

A summary of recent works.

Toward a breast cancer prevention vaccine

Our goal is a vaccine that prevents breast cancer before a first diagnosis. This summary maps the evidence we need, the data worth collecting and the collaborations that could make that research possible.

· 12 pages · 13 sources

AI-assisted literature summary. Not peer reviewed or medical advice.

From evidence
to a connected study.

Read the research brief

Open questions.

01

What appears before cancer?

Connect normal, high-risk and precursor tissue to molecular and HLA-presentation evidence. A tumor-only dataset misses the earlier window.

02

Can it be targeted safely?

Link candidate antigens to functional immunity and normal-tissue safety, including physiological context and negative results.

03

Does it prevent a first cancer?

Track first diagnoses, confirmed cancer-free follow-up and harms. Immune activity alone does not establish clinical benefit.

Research informing the plan.

  1. NCI-funded researchFY2025

    Chimeric RNA driven neopeptide vaccine for prevention of breast cancer in germline BRCA1/2 carriers (opens in a new tab)

    Primary-prevention research aims, not demonstrated protection in people or a Tesserie partnership.

  2. Cleveland ClinicDecember 2025

    Final Phase 1 findings from a preventive breast cancer vaccine study (opens in a new tab)

    Institutional announcement on safety and immune responses; not proof of preventing a first breast cancer.

  3. Nature2026

    Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC (opens in a new tab)

    Adjuvant clinical study; not randomized proof of reduced recurrence and not a primary-prevention trial.

  4. Nature2026 issue

    Parity and lactation induce T-cell-mediated breast cancer protection (opens in a new tab)

    Human observations and mouse experiments inform tissue immunity; not a preventive-vaccine trial or reproductive advice.

  5. Journal of Clinical Investigation2024 issue

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